Phd thesis in medicinal chemistry

Phd thesis in medicinal chemistry

FindAPhD. Search Funded PhD Research Projects in Pharmaceutical / Medicinal Chemistry. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world Our "Medicinal Chemistry" experts can research and write a NEW, ONE-OF-A-KIND, ORIGINAL dissertation, thesis, or research proposal—JUST FOR YOU—on the precise "Medicinal Chemistry" topic of your choice. Our final document will match the EXACT specifications that YOU provide, guaranteed. We have the necessary skills, knowledge, and experience to complete virtually any Advances in Heterocyclic Synthesis through Ring Expansions and Flow Chemistry . Charaschanya, Manwika (University of Kansas, ) This dissertation comprises three chapters, which focus on the development of new synthetic methodologies and the construction of a screening collection

Medicinal Chemistry Dissertations and Theses

View more. The following person has been designated to handle inquiries regarding the non-discrimination policies: Director of the Office of Institutional Opportunity and Access, IOA ku. eduW. Campus Road, Room A, Lawrence, KS, TTY. Medicinal Chemistry Dissertations and Theses KU ScholarWorks Medicinal Chemistry Medicinal Chemistry Dissertations and Theses.

JavaScript is disabled for your browser. Some features of this site may not work without it. Medicinal Chemistry Dissertations and Theses Browse by. Phd thesis in medicinal chemistry modern molecular understanding of biological systems relies on integration of principles, practices, phd thesis in medicinal chemistry, and techniques from diverse fields such as molecular biology, biochemistry, and biophysics.

This approach has provided Discovery of Novel Inhibitors of Cellular Efflux by High-Content Screening with a Fluorescent Mimic of Taxol  Smith, Tomas Joseph University of Kansas Fluorescence-based assays play key roles in drug discovery and development.

These assays are widely used due to the widespread availability of fluorescent probes and highly sensitive detection platforms. This method is a Synthesis and Evaluation of Fluorescent Tools for Studies of Cancer Biology  Gao, phd thesis in medicinal chemistry, Zhe University of Kansas A key enabling technology in biological sciences involves fluorescent probes.

These probes are typically small molecules, proteins, or nucleic acids that either possess intrinsic fluorescence or are linked to a fluorophore Strategies for the Fluorine-Retentive Functionalization of Gem-Difluoroalkenes  Orsi, Douglas University of Kansas Fluorination is an important strategy for perturbing the biophysical properties of compounds in medicinal chemistry. Specifically, fluorination modulates both the pharmacodynamic and pharmacokinetic properties of bioactive Studies of novel targeted drug delivery systems and molecular probes of cancer biology  Knewtson, Kelsey Erin University of Kansas Cancer is a complex family of diseases.

As our understanding of cancer biology has improved, so has our ability to treat the pathology associated with this condition. Traditional anticancer therapeutics lack selectivity Investigation of the Phenyl Ring of Imidazoquinolines  Hunt, Jordan Robert University of Kansas For example, Imiquimod and Resiquimod have been shown to act as vaccine adjuvants, enhancing A New Generation of Isoform Selective Hsp90 Inhibitors: Targeting the Cytosolic Hsp90 Isoforms  Mishra, Sanket University of Kansas Heat shock protein 90 kDa Hsp90 is a member of the molecular chaperone family of proteins that processes newly synthesized polypeptides into their three-dimensional and biologically active form.

In addition, Hsp90 assists The Development of Organelle-localized Hsp90 Isoform-selective Inhibitors  Crowley, Vincent Matthew University of Kansas Molecular chaperones are responsible for the maturation of nascent polypeptides and the re-maturation of denatured proteins. One chaperone family that has emerged as an attractive therapeutic target is the 90 kDa heat shock Exploration of Salvinorin A for the Development of Pain and Addiction Therapies  Crowley, Rachel S.

University of Kansas In the search for effective methods to mitigate the increasing rates of abuse and addiction of illicit substances, a variety of neurological pathways have been explored. Towards this goal of reducing drug abuse and ultimately Development of Bisamides as Kappa Opioid Receptor Agonists. Potency Enhancement of Sulfonamide-based Kappa Opioid Receptor Antagonists.

Asymmetric Acyl Transfer Reactions Catalyzed by a Cyclic Peptide. The structure-activity relationship SAR expansion was carried out on bisamides KOR agonists. Previous four-step linear synthetic route was replaced by Ugi Design and synthesis of cyclic analogs of the kappa opioid receptor antagonist arodyn  Gisemba, Solomon University of Kansas Opioid receptors are important therapeutic targets for mood disorders and pain.

Kappa opioid receptor KOR antagonists have recently shown potential for treating drug addiction and depression, phd thesis in medicinal chemistry. Arodyn Ac[Phe1,2,3,Arg4,D-Ala8]Dyn Advances in Heterocyclic Synthesis through Ring Expansions and Flow Chemistry  Charaschanya, Manwika University of Kansas This dissertation comprises three chapters, phd thesis in medicinal chemistry, which focus on the development of new synthetic methodologies and the construction of a screening collection.

An Application of the Schmidt Reaction: Construction of an Azasteroid Exploration of the Mechanisms of Adjuvanticity for Toll-like Receptor Agonists  Salyer, Alex Christopher Dean University of Kansas Small-molecule agonists have been identified for Toll-like Receptors TLR 2, TLR4, TLR7 and TLR8 thus far, and chemotypes other than those of canonical ligands are yet to be explored for a number of innate immune receptors. The Development of Small Molecules that Modulate Molecular Chaperones Hsp90 and Hsp70  Forsberg, Leah Kathleen University of Kansas The heat shock proteins are a highly conserved protein family that are constitutively expressed and function as molecular chaperones.

Molecular chaperones 90kDa Heat Shock Protein Hsp90 and 70kDa Heat Shock Protein Hsp Synthetic Strategies to Access Biologically Important Fluorinated Motifs: Fluoroalkenes and Difluoroketones  Yang, Ming-Hsiu University of Kansas phd thesis in medicinal chemistry, Fluorine plays an important role in drug design, because of some unique features imparted by fluorine.

The incorporation of fluorine into small molecules can modulate molecular physicochemical properties, metabolic stability, Design and Synthesis of Functionally Selective Kappa Opioid Receptor Ligands  Johnson, Stephanie University of Kansasphd thesis in medicinal chemistry, Phd thesis in medicinal chemistry ability of ligands to differentially regulate the activity of signaling pathways coupled to a receptor potentially enables researchers to optimize therapeutically relevant efficacies, while minimizing activity at Copper-Catalyzed Decarboxylative Trifluoromethylation Reactions  Ambler, Brett R.

Trifluoromethanes play an important role in medicinal chemistry, and methods that enable the rapid synthesis of trifluoromethanes from common functional groups are essential for the synthesis of bioactive compounds. An Improved Synthesis of the Pacific Blue Fluorophore and Fluorescence-based Studies of Receptor-Ligand Interactions  Lee, Molly Marie University of Kansas Early-stage drug discovery and chemical biology projects often use fluorescence-based assays to obtain information about biological interactions and cellular processes.

However, many of the best and brightest fluorophores Unfolding the Hsp90 Foldasome: Structure-Activity Relationship Studies on EGCG and Development of Isoform-Selective Inhibitors  Khandelwal, Anuj University of Kansas The 90 kDa heat shock proteins Hsp90 are critical for the maintenance of cellular phd thesis in medicinal chemistry and mitigate the effects of cellular stress and therefore, play an important role in cell survival. Hsp90, as a molecular The Peterson laboratory has had a long-standing interest in fluorescent probes of biological systems.

My research in the Peterson group has focused on the design, synthesis, and biological evaluation of fluorescent small Search KU ScholarWorks. This Collection, phd thesis in medicinal chemistry. Author Singh, Gurpreet phd thesis in medicinal chemistry Ambler, Brett R. View More Subject Organic chemistry 41 Chemistry 31 Pharmaceutical sciences 28 Biochemistry 19 Pharmaceutical chemistry View More Date Issued - 57 - Login Register.

View Usage Statistics View Search Statistics View Workflow Statistics. RSS Feeds RSS 1. Contact KU ScholarWorks Lawrence, KS Maps. Contact KU Lawrence, KS Maps.

VLOG: first day of my PhD in Medicinal Chemistry����‍��

, time: 9:36

The PhD in Medicinal Chemistry | College of Pharmacy - University of Minnesota

Medicinal C Mehdie cinm al Ci hs emt ir styry,, PP hDh D 1 The PhD Program in Medicinal Chemistry educates and trains students in the design and synthesis of novel, biologically active compounds and in delineating their mechanisms of action using biochemical, biophysical, and pharmacological approaches. Research specializations are available FindAPhD. Search Funded PhD Research Projects in Pharmaceutical / Medicinal Chemistry. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world Advanced Entry PhD Program Requirements. The PhD Program in Medicinal Chemistry and Drug Discovery educates and trains students in the design and synthesis of novel, biologically active compounds and in delineating their mechanisms of action using biochemical, biophysical, and pharmacological approaches. Research specializations are available in synthetic,